In-Silico Analysis of Tghdac3 (Transcription Regulator) as Drug Target in Toxoplasma gondii

Abstract

Toxoplasma gondii are parasites of major medical importance that belong to the Apicomplexa phylum of protozoa. These parasites transform into various stages during their life cycle and express a specific set of proteins at each stage. Although little is yet known of how gene expression is controlled in Apicomplexa, histone modifications, particularly acetylation, are emerging as key regulators of parasite differentiation and stage conversion. The experimental 3D structure of this protein has not yet been determined. In this study, we have used homology modelling techniques to generate the 3D structure of TgHDAC3and validate the model by using different bioinformatics approaches. This study also demonstrated the phylogenetic study of TbHDAC3. Phylogram of TbHDAC3 with distinctly and closely related species deduced similarity with Neospora caninum Liverpool, Eimeria tenella and Hammondia hammondi.