Synthesis and Biological Activity a New Substituted Schiff Bases

Abstract

Schiff bases are synthesized by different methods by the condensation between primary amines and aldehyde or ketones. From literature survey, it was cleared that many work on Schiff bases is going on. But each work is only concerns with conventional method and grinding method. But very few reports were observed on synthesis of Schiff bases by green approach. Therefore, in present work some substituted Schiff bases are prepared from primary amines and substituted aromatic aldehydes. Eight new series of biologically active variously substituted Schiff bases with general formula, R1N=CHR2. With differently substituted aromatic aldehydes were synthesized by microwave irradiation technique. Such compounds were characterized by different physico-chemical techniques like, melting point, elemental analysis, IR . The Compounds have been screened for their in vitro biological activities against bacteria and fungi.